静脉移植物狭窄的病因学。

The aetiology of vein graft stenoses.

作者信息

Davies A H, Magee T R, Sheffield E, Baird R N, Horrocks M

机构信息

Department of Vascular Studies, Bristol Royal Infirmary, UK.

出版信息

Eur J Vasc Surg. 1994 Jul;8(4):389-94. doi: 10.1016/s0950-821x(05)80955-7.

DOI:10.1016/s0950-821x(05)80955-7

PMID:8088388

Abstract

The aetiology of vein graft stenosis is poorly understood. In a cohort of 88 patients, the mean internal diameter of the vein grafts that developed a stenosis was 3.7 (3.1-4.2) mm compared to 4.7 (4.4-5.0) mm in those that did not (p = 0.006). The mean lowest compliance value in the 11 patients who developed a stenosis was 0.1 (0.07-0.13) % per mmHg compared to 0.21 (0.19-0.23) % per mmHg in the rest (p < 0.001). The presence of vein incompetence, site of tributaries or valves and the degree of endothelial cell loss were not related to the development of vein graft stenoses. The presence of a macrophage infiltrate (p < 0.001), lymphocyte infiltrate (p < 0.025) and subendothelial smooth muscle cells (p < 0.05) were all significantly more common in those grafts that developed a stenosis. Vein quality is an important factor in the development of graft stenoses.

摘要

静脉移植物狭窄的病因尚不清楚。在一个88名患者的队列中，发生狭窄的静脉移植物的平均内径为3.7（3.1 - 4.2）mm，而未发生狭窄的静脉移植物平均内径为4.7（4.4 - 5.0）mm（p = 0.006）。发生狭窄的11名患者的平均最低顺应性值为每毫米汞柱0.1（0.07 - 0.13）%，其余患者为每毫米汞柱0.21（0.19 - 0.23）%（p < 0.001）。静脉功能不全、分支或瓣膜的位置以及内皮细胞丢失程度与静脉移植物狭窄的发生无关。巨噬细胞浸润（p < 0.001）、淋巴细胞浸润（p < 0.025）和内皮下平滑肌细胞（p < 0.05）在发生狭窄的移植物中均明显更为常见。静脉质量是移植物狭窄发生的一个重要因素。