Forgione F N, Acquati F, Caico S I, Tagliagambe L
Divisione di Cardiologia, Ospedale Multizonale, Varese.
G Ital Cardiol. 1994 Jun;24(6):755-61.
A 29-year-old woman presented with incessant atrial tachycardia and tachycardia-related cardiomyopathy during the last weeks of pregnancy. At 40 weeks of gestation a healthy infant was delivered by Cesarean section. Various medical treatments and two attempts of electrical cardioversion were ineffective in restoring sinus rhythm. Electrophysiologic study with endocardial activation mapping confirmed the diagnosis and thereafter radiofrequency transcatheter ablation of the ectopic focus was successfully carried out and sinus rhythm was restored. Serial 24-h Holter monitoring at 1, 3, and 6 months showed the persistence of sinus rhythm. Echocardiographic examinations demonstrated a very rapid recovery of both left ventricular diameters and ejection fraction to normal limits within two weeks after ablation. In this case-report the potential role of pregnancy and recent advances in the understanding and treatment of ectopic atrial tachycardia are summarized. Although endocardial mapping is difficult, radiofrequency catheter ablation appears to be the elective technique for the treatment of this particular arrhythmia, often refractory to antiarrhythmic drugs. Moreover, this case highlights that tachycardia-related cardiomyopathy should be seriously considered in any patient with apparently end-stage dilated cardiomyopathy and persistent tachycardia.
一名29岁女性在妊娠最后几周出现持续性房性心动过速及心动过速相关的心肌病。妊娠40周时通过剖宫产分娩出一名健康婴儿。多种药物治疗及两次电复律尝试均未能恢复窦性心律。心内膜激动标测的电生理研究确诊后,成功进行了经导管射频消融异位灶,恢复了窦性心律。术后1个月、3个月及6个月的连续24小时动态心电图监测显示窦性心律持续存在。超声心动图检查显示消融术后两周内左心室直径和射血分数均迅速恢复至正常范围。本病例报告总结了妊娠的潜在作用以及异位房性心动过速在认识和治疗方面的最新进展。尽管心内膜标测困难,但射频导管消融似乎是治疗这种对抗心律失常药物常常难治的特殊心律失常的首选技术。此外,该病例突出表明,对于任何患有明显终末期扩张型心肌病且持续性心动过速的患者,均应认真考虑心动过速相关的心肌病。