Zittoun R, Bernadou A, James J M, Soria J, Bousser J
Acta Haematol. 1975;53(4):241-8. doi: 10.1159/000208189.
The authors report a case of acute myelo-monocytic leukaemia occurring in a patient, 3 years after the beginning of a typical paroxysmal nocturnal haemoglobinuria (PNH). An intermediate phase characterized by worsening of the anaemia was observed, with disappearance of the in vitro haemolysis tests. The kinetic studies showed a replacement of the early peripheral haemolysis by a bone marrow insufficiency with intra-medullary cell death. A review of the five previous reported cases of this association show that PNH is generally a typical one, so that acute leukaemia must be considered as an unfrequent but possible complication of PNH.
作者报告了1例急性粒-单核细胞白血病病例，该病例发生在1例典型阵发性睡眠性血红蛋白尿（PNH）开始3年后。观察到一个以贫血恶化为特征的中间期，体外溶血试验消失。动力学研究显示，早期外周溶血被骨髓功能不全伴髓内细胞死亡所取代。对之前报道的5例这种关联病例的回顾表明，PNH通常是典型的，因此急性白血病必须被视为PNH一种罕见但可能的并发症。
