Osada H
Department of Obstetrics and Gynecology, Nihon University School of Medicine, Tokyo.
Nihon Sanka Fujinka Gakkai Zasshi. 1994 Aug;46(8):735-41.
Achieving patency of the Fallopian tubes by selective transcervical hysterosalpingography, transcervical tuboplasty using PTCA-balloon catheters and microsurgical techniques has a success rate in excess of 90%, however, the pregnancy rates following these procedures is still less than 50%. Thus, the surgical approach for the treatment of tubal infertility which may improve post therapeutic pregnancy rates remain as yet unsolved problems. Modalities proposed include tubal transplants and prosthetic functional tubes. The purpose of surgical approaches to treat tubal infertility is to regain the physiologic ability to become pregnant without further clinical intervention. This has the advantage of reducing both economic and psychologic stress in the previously infertile couple, thus is clinically highly desirable, when achievable. However as there are limits for the indications of these procedures, for instance in occluded tubes, where disease has caused irreversible damage to the tubal endothelium, physical restoration of patency may not restore fertility. Thus, this discussion covers the limitations of surgical procedures and alternate procedures when surgical procedures are inadequate. We further investigated the tubal influences on the establishment and development of the zygote, and the tubal influences such as pressure and exudate dynamics on their transport within the tube. Thus, the advances in enhanced fertility studies, including in vitro fertilization have led more definitive understanding of fertilization, development of the zygote and its nidation, necessitating more intensive investigation of tubal physiology. In conclusion, where possible, surgical procedures which may allow physiologic pregnancies without additional clinical intervention are an attractive approach which should be utilized maximally when acceptable pregnancy rates can be expected.
通过选择性经宫颈子宫输卵管造影术、使用PTCA球囊导管的经宫颈输卵管成形术以及显微外科技术实现输卵管通畅,成功率超过90%,然而,这些手术后的妊娠率仍低于50%。因此,治疗输卵管性不孕的手术方法,即可能提高治疗后妊娠率的方法,仍然是尚未解决的问题。提出的方法包括输卵管移植和人工功能性输卵管。治疗输卵管性不孕的手术方法的目的是恢复在无进一步临床干预情况下受孕的生理能力。这具有减轻既往不孕夫妇经济和心理压力的优点,因此在可行时,临床上非常可取。然而,由于这些手术的适应证有限,例如在输卵管阻塞的情况下,疾病已对输卵管内皮造成不可逆损害,恢复通畅可能无法恢复生育能力。因此,本讨论涵盖了手术方法的局限性以及手术方法不足时的替代方法。我们进一步研究了输卵管对受精卵着床和发育的影响,以及输卵管内压力和渗出液动力学等对其在输卵管内运输的影响。因此,包括体外受精在内的提高生育力研究的进展,使人们对受精、受精卵发育及其着床有了更确切的认识,这就需要对输卵管生理学进行更深入的研究。总之,在可能的情况下,能够实现无需额外临床干预的生理性妊娠的手术方法是一种有吸引力的方法,当预期有可接受的妊娠率时,应最大限度地加以利用。