多发性硬化症的良性形式：MRI显示疾病活动频率较低且炎症较轻的证据。
Benign form of multiple sclerosis: MRI evidence for less frequent and less inflammatory disease activity.
作者信息
Kidd D, Thompson A J, Kendall B E, Miller D H, McDonald W I
机构信息
NMR Research Group, National Hospital, London, UK.
出版信息
J Neurol Neurosurg Psychiatry. 1994 Sep;57(9):1070-2. doi: 10.1136/jnnp.57.9.1070.
Abstract
Data from two serial studies comparing the MRI activity of two groups of 11 patients, one with early relapsing-remitting (mean disease duration 3.5 years), the other benign (mean disease duration 22 years) multiple sclerosis are presented. Those with benign disease developed fewer new or enlarging lesions, and such lesions that occurred had a lower incidence of gadolinium enhancement, a marker of inflammation. These results, when considered in conjunction with other published studies, suggest that both the frequency of new lesions and the amount of inflammation within them influence the development of disability in multiple sclerosis.
摘要
本文展示了两项系列研究的数据，这两项研究比较了两组各11名患者的MRI活动情况，一组为早期复发缓解型多发性硬化患者（平均病程3.5年），另一组为良性多发性硬化患者（平均病程22年）。患有良性疾病的患者出现新的或扩大的病灶较少，而且出现的此类病灶钆增强（炎症标志物）的发生率较低。这些结果与其他已发表的研究相结合表明，新病灶的频率及其内部的炎症程度均会影响多发性硬化症患者残疾的发展。
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