原发性高血压患者的血小板体积并未增加。
Platelet volume is not increased in essential hypertension.
作者信息
Bath P M, Carney C, Markandu N D, MacGregor G A
机构信息
Blood Pressure Unit, St. George's Hospital Medical School, London, UK.
出版信息
J Hum Hypertens. 1994 Jun;8(6):457-9.
Platelet size, a determinant of platelet function, is a newly emerging risk factor for atherothrombosis. Platelet volume has previously been shown, using less than ideal methodology, to be increased in essential hypertension. Mean platelet volume was measured in 38 patients with essential hypertension and 38 paired normotensive control subjects matched for age and sex. Platelet volume, median (interquartile ranges) 7.7 (7.2-8.5) fl vs. 7.8 (7.5-8.4) fl (2P = 0.40), platelet count 242 (220-288) x 10(9)/l vs. 243 (215-292) x 10(9)/l (2P = 0.68) and platelet mass 1.91 (1.67-2.18) ml/l vs. 1.84 (1.70-2.23) ml/l (2P = 0.90) were similar in the hypertensive patients (supine BP: SBP 168 (153-178) mmHg, DBP 103 (98-110) mmHg) and control subjects (SBP 126 (112-138) mmHg, DBP 78 (74-82) mmHg). Serum lipids and plasma glucose and creatinine concentrations were not different between the groups. Mean BP did not correlate with platelet volume (rs = -0.100, 2P = 0.39) or platelet count (rs = 0.111, 2P = 0.34). These data suggest that platelet volume is not altered in essential hypertension.
血小板大小是血小板功能的一个决定因素，是动脉粥样硬化血栓形成新出现的一个危险因素。以前采用不太理想的方法已显示原发性高血压患者的血小板体积增加。对38例原发性高血压患者和38例年龄及性别相匹配的血压正常对照者测量了平均血小板体积。高血压患者（仰卧位血压：收缩压168（153 - 178）mmHg，舒张压103（98 - 110）mmHg）和对照者（收缩压126（112 - 138）mmHg，舒张压78（74 - 82）mmHg）的血小板体积，中位数（四分位间距）分别为7.7（7.2 - 8.5）fl对7.8（7.5 - 8.4）fl（P = 0.40），血小板计数分别为242（220 - 288）×10⁹/L对243（215 - 292）×10⁹/L（P = 0.68），血小板质量分别为1.91（1.67 - 2.18）ml/L对1.84（1.70 - 2.23）ml/L（P = 0.90），均相似。两组间血清脂质、血浆葡萄糖和肌酐浓度无差异。平均血压与血小板体积（rs = -0.100，P = 0.39）或血小板计数（rs = 0.111，P = 0.34）均无相关性。这些数据提示原发性高血压患者的血小板体积未改变。
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