Minemura K, Ichinose Y, Utsumi K, Kuriyama Y, Kawanishi Y, Torii Y, Yonemaru M, Nakano M, Toyama K
First Department of Internal Medicine, Tokyo Medical College, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1994 Jun;32(6):544-9.
We attempted to verify the clonality of proliferating cells in broncho-alveolar lavage fluid (BALF) by using a sophisticated technique known as kappa-lambda imaging. We applied this method to BALF lymphocytes from 3 cases suspected of having primary pulmonary B-cell lymphoma, by transbronchial lung biopsy, and from 2 cases with B-cell lymphoma revealing abnormal shadows. (One was diagnosed as small cell carcinoma, the other mycotic infection). B-cell monoclonality was found in the former 3 cases, but not in the latter 2 cases. We conclude that kappa-lambda imaging in BALF lymphocytes is useful for diagnosing B-cell lymphoma of the lung.
我们试图通过使用一种称为κ-λ成像的精密技术来验证支气管肺泡灌洗液（BALF）中增殖细胞的克隆性。我们将该方法应用于3例经支气管肺活检怀疑患有原发性肺B细胞淋巴瘤的患者以及2例显示异常阴影的B细胞淋巴瘤患者的BALF淋巴细胞。（其中1例被诊断为小细胞癌，另1例为霉菌感染）。在前3例中发现了B细胞单克隆性，而后2例中未发现。我们得出结论，BALF淋巴细胞中的κ-λ成像有助于诊断肺B细胞淋巴瘤。
