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[冒烟型成人T细胞白血病患者并发肺诺卡菌病与卡氏肺孢子虫肺炎]

[Pulmonary nocardiosis concurrent with Pneumocystis carinii pneumonia in a case of smoldering adult T-cell leukemia].

作者信息

Owan I, Sugama I, Nakamoto A, Kusano N, Fukuhara H, Kaneshima H, Saito A

机构信息

First Department of Internal Medicine, Faculty of Medicine, University of Ryukyus, Okinawa, Japan.

出版信息

Nihon Kyobu Shikkan Gakkai Zasshi. 1994 Jun;32(6):581-6.

PMID:8089947
Abstract

A 76-year-old man, with concomitant pulmonary nocardiosis and Pneumocystis carinii (PC) pneumonia, is described. He suffered from smoldering type adult T-cell leukemia and strongyloidiasis. Chest X-rays showed bilateral infiltrative shadows. Nocardia asteroides was isolated from sputum and bronchofiberscopic aspirates. PC was not detected, however, despite the chest X-ray raising the suspicion of PC pneumonia. Since PC antigen was detected by immunoelectrophoresis in the absence of other clinical or histologic data, we diagnosed a latent PC infection. He improved with the use of cefuzonam and ST compounds, but experienced recurrence five months after discharge. N. asteroides and PC were detected from sputum on the second admission. As multiple concurrent infections with opportunistic organisms are not uncommon in immunocompromised hosts, we must maintain a high index of suspicion for opportunistic infection in cases such as this one.

摘要

本文描述了一名76岁男性,同时患有肺诺卡菌病和卡氏肺孢子虫(PC)肺炎。他还患有成人T细胞白血病(隐匿型)和类圆线虫病。胸部X线显示双侧浸润性阴影。痰液和支气管纤维镜抽吸物中分离出星形诺卡菌。尽管胸部X线检查怀疑有PC肺炎,但未检测到PC。由于在缺乏其他临床或组织学数据的情况下通过免疫电泳检测到PC抗原,我们诊断为潜伏性PC感染。使用头孢唑南和ST化合物后病情好转,但出院五个月后复发。第二次入院时痰液中检测到星形诺卡菌和PC。由于免疫功能低下宿主中多种机会性生物体并发感染并不罕见,对于此类病例,我们必须高度怀疑存在机会性感染。

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