Cinquegrana G, Spinelli L, De Magistris L, Piedimonte V, Petraglia N, Curzio A
Divisione di Medicina d'Urgenza e Sezione di UTIC, Ospedale A. Cardarelli, Napoli.
Minerva Cardioangiol. 1994 May;42(5):211-5.
In patients (pt) with coronary artery disease diastolic duration is an important determinant of myocardial oxygen supply. To assess the effects of physical training on diastolic duration, twelve male pt with previous infarction were studied. During 12 month training program the physical exercise was of progressively increasing intensity, duration and frequency. Training induced a significant reduction in heart rate. Both systolic and diastolic blood pressure were unchanged. The mean values of electromechanical systole were lower after training. On the contrary, the training induced a lengthening of diastolic duration expressed as percentage of cardiac cycle (% diastole) from 51.4 +/- 2.6 to 57.5 +/- 3.8% (p < 0.001). Thus, this results validate the hypothesis that physical exercise training can improve myocardial perfusion through an increase in diastolic duration, partially independent of bradycardia.
在冠心病患者中，舒张期持续时间是心肌氧供的重要决定因素。为评估体育锻炼对舒张期持续时间的影响，对12名曾有过心肌梗死的男性患者进行了研究。在为期12个月的训练计划中，体育锻炼的强度、持续时间和频率逐渐增加。训练导致心率显著降低。收缩压和舒张压均未改变。训练后机电收缩期的平均值较低。相反，训练使以心动周期百分比（%舒张期）表示的舒张期持续时间从51.4±2.6延长至57.5±3.8%（p<0.001）。因此，这些结果证实了体育锻炼训练可通过增加舒张期持续时间来改善心肌灌注这一假设，且部分独立于心动过缓。
