Differential phasic modulation of short and long latency afferent sensory transmission to single neurons in the primary somatosensory cortex in behaving rats.

Single neurons were recorded in the forepaw area of the primary somatosensory (SI) cortex of awake rats during rest and running behavior. Locomotor step cycle dependent changes of the transmission of the short (4.5 +/- 0.1-10.5 +/- 0.1 ms, SEURs) and the long (10.6 +/- 0.6-28.5 +/- 2.3 ms, LEURs) latency evoked unit responses were tested by generating post-stimulus time histograms of these neurons' responses to stimulation through electrodes chronically implanted under the skin of the forepaw. Times of footfall were determined by way of frame-by-frame analyses of video recordings, and peri-footfall histograms were generated to differentiate a total of 55 SI cortical neurons into two types: footfall responsive (n = 37) and footfall unresponsive (n = 18) neurons. Peri-footfall gating patterns were determined for both types of cells. The SEURs and the LEURs showed significantly different phasic sensory modulation patterns. A major difference in sensory modulations between footfall responsive and footfall unresponsive cells was noted during the swing phase of the locomotor step cycle. In footfall responsive cells, the SEURs were suppressed most strongly just after footfall, while the LEURs were phasically suppressed following both footfall and footoff. The SEURs were disinhibited during the swing phase. In footfall unresponsive cells, the SEURs were tonically suppressed during the whole locomotor step cycle phases. However, the LEURs were phasically facilitated during the early swing phase.(ABSTRACT TRUNCATED AT 250 WORDS)