Pancera P, Sheiban I, Ribul M, Priante F, De Marchi S, Zannoni M, Arosio E, Lechi A
University of Verona, Italy.
Panminerva Med. 1994 Mar;36(1):25-9.
To evaluate the modifications induced by chronic treatment with a new formulation of nicardipine (slow release) on the hemodynamic parameters in peripheral artery and left ventricle diastolic function.
Ten mild to moderate essential hypertensive male patients (mean age 42 years, range 32-54 years) received nicardipine slow release (40 mg b.i.d.) for six months. Peripheral hemodynamic and cardiac parameters were evaluated by duplex scanner, coupled with a plethysmographic method, basally (T0) and after 1 (T1) and 6 months' treatment (T2).
Blood pressure showed a significant reduction after 1 month (mean blood pressure 109 +/- 2 vs 124 +/- 3 mmHg, M +/- SE, p < 0.001), which was maintained after 6 months (mean blood pressure 112 +/- 3 mmHg, p < 0.001), while heart rate showed only a slight, non-significant increase. There were highly significant changes in distensibility (0.29 +/- 0.02 vs 0.16 +/- 0.01 s2.cm-2, T2 vs T0, p < 0.001), characteristic impedance (55 +/- 3 vs 78 +/- 3 dyn.s.cm-5.10(2), T2 vs T0, p < 0.001) and local resistances (71 +/- 5 vs 118 +/- 4 mmHg.ml-1. s, T2 vs T0, p < 0.001) in the brachial artery, and also in left ventricle posterior wall diastolic thickness (10.2 +/- 0.4 vs 11.5 +/- 0.3 mm, T2 vs T0, p < 0.05), end diastolic volume (127 +/- 3 vs 109 +/- 3 ml, T2 vs T0, p < 0.01) and mass/volume index (1.21 +/- 0.03 vs 1.35 +/- 0.03, p < 0.05).
The antihypertensive efficacy of nicardipine slow release, with only two daily administrations, allows the restoration of the dumping function of the large arteries, and the regression of the functional modifications affecting the left ventricular diastole.
评估新型制剂硝苯地平（缓释）长期治疗对外周动脉血流动力学参数及左心室舒张功能的影响。
10例轻度至中度原发性高血压男性患者（平均年龄42岁，范围32 - 54岁）接受硝苯地平缓释片（40mg，每日2次）治疗6个月。在治疗前（T0）、治疗1个月后（T1）及6个月后（T2），采用双功能扫描仪结合体积描记法评估外周血流动力学和心脏参数。
治疗1个月后血压显著降低（平均血压109±2 vs 124±3 mmHg，M±SE，p < 0.001），6个月后仍维持此水平（平均血压112±3 mmHg，p < 0.001），而心率仅轻微升高，无统计学意义。肱动脉的扩张性（0.29±0.02 vs 0.16±0.01 s2.cm - 2，T2 vs T0，p < 0.001）、特性阻抗（55±3 vs 78±3 dyn.s.cm - 5.10(2)，T2 vs T0，p < 0.001）和局部阻力（71±5 vs 118±4 mmHg.ml - 1.s，T2 vs T0，p < 0.001）有极显著变化，左心室后壁舒张期厚度（10.2±0.4 vs 11.5±0.3 mm，T2 vs T0，p < 0.05）、舒张末期容积（127±3 vs 109±3 ml，T2 vs T0，p < 0.01）和质量/容积指数（1.21±0.03 vs 1.35±0.03，p < 0.05）也有显著变化。
硝苯地平缓释片每日仅服用2次，具有降压效果，可恢复大动脉的缓冲功能，并逆转影响左心室舒张的功能改变。
