Peltier R L, Emmett-Oglesby M W, Thomas W H, Schenk S
Department of Pharmacology, University of North Texas HSC at Fort Worth 76107-2699.
Pharmacol Biochem Behav. 1994 Jun;48(2):473-8. doi: 10.1016/0091-3057(94)90555-x.
Ritanserin, a 5-HT2/1C antagonist, has been suggested to reduce the preference for cocaine in rats. In the present experiment, the action of ritanserin was investigated in locomotor activity, cocaine drug discrimination, and cocaine self-administration paradigms in rats. A low dose of ritanserin (1.0 mg/kg) was without effect on locomotor activity, while a higher dose (10.0 mg/kg) reduced both horizontal and vertical locomotor activity counts during the first 30 min of the test session. Ritanserin (0.32-32 mg/kg) did not significantly affect the discrimination of 10 mg/kg of cocaine, nor did a dose of 10.0 mg/kg significantly modify the dose-effect curve for cocaine discrimination. Ritanserin (1.0 and 10.0 mg/kg) had no significant effect on the dose-response curve for cocaine self-administration. Thus, ritanserin was without effect against either the discriminative or reinforcing stimulus effects of cocaine, suggesting that ritanserin has limited efficacy as a potential treatment for cocaine abuse.
利坦色林是一种5-羟色胺2/1C拮抗剂，据报道它能降低大鼠对可卡因的偏好。在本实验中，研究了利坦色林在大鼠自发活动、可卡因药物辨别和可卡因自我给药范式中的作用。低剂量的利坦色林（1.0毫克/千克）对自发活动没有影响，而高剂量（10.0毫克/千克）在测试期的前30分钟内减少了水平和垂直自发活动计数。利坦色林（0.32-32毫克/千克）对10毫克/千克可卡因的辨别没有显著影响，10.0毫克/千克的剂量也没有显著改变可卡因辨别的剂量效应曲线。利坦色林（1.0和10.0毫克/千克）对可卡因自我给药的剂量反应曲线没有显著影响。因此，利坦色林对可卡因的辨别或强化刺激作用均无效果，这表明利坦色林作为可卡因滥用的潜在治疗药物，其疗效有限。
