Shekhar A, Katner J S, Rusche W P, Sajdyk T J, Simon J R
Department of Psychiatry, Indiana University School of Medicine, Indianapolis 46202.
Pharmacol Biochem Behav. 1994 Jun;48(2):525-9. doi: 10.1016/0091-3057(94)90564-9.
The norepinephrine (NE), dopamine (DA), and serotonin (5-HT) systems are thought to be important in the development of anxiety and stress. The dorsomedial hypothalamus (DMH) of rats has been implicated in the regulation of physiological and behavioral responses associated with fear and anxiety. In order to elucidate the interactions between the monoamine systems and the DMH, we studied the effects of subjecting rats to the fear-potentiated startle test, a commonly used test of anxiety in rats, on the NE, DA, and 5-HT levels in the DMH. Rats in the potentiated startle test, but not those exposed to just foot shocks or acoustic startle, showed significantly higher levels of NE and DA in the DMH compared to cage controls. In contrast, foot shocks significantly elevated the 5-HT levels in the DMH.
去甲肾上腺素（NE）、多巴胺（DA）和5-羟色胺（5-HT）系统被认为在焦虑和应激的发生发展中起重要作用。大鼠的背内侧下丘脑（DMH）与恐惧和焦虑相关的生理及行为反应的调节有关。为了阐明单胺系统与DMH之间的相互作用，我们研究了让大鼠接受恐惧增强型惊吓试验（一种常用于大鼠焦虑测试的方法）对DMH中NE、DA和5-HT水平的影响。与笼养对照组相比，接受增强型惊吓试验的大鼠（而非仅接受足部电击或听觉惊吓的大鼠）DMH中的NE和DA水平显著更高。相反，足部电击显著提高了DMH中的5-HT水平。
