锂对情感障碍患者下丘脑 - 垂体 - 甲状腺功能的影响。
Effect of lithium on hypothalamic-pituitary-thyroid function in patients with affective disorders.
作者信息
McLarty D G, O'Boyle J H, Spencer C A, Ratcliffe J G
出版信息
Br Med J. 1975 Sep 13;3(5984):623-6. doi: 10.1136/bmj.3.5984.623.
Abstract
Hypothalamic-pituitary-thyroid (H.P.T.) function was assessed in 17 patients on maintenance doses of lithium carbonate for a mean period of 21 months (range 1-67 months) and by serial studies on four patients from the start of lithium treatment for a maximum of six months. An exaggerated thyrotrophin (TSH) response to intravenous thyrotrophin-releasing hormone (TRH) occurred in 14 of the 17 patients on maintenance treatment, though basal TSH levels were raised in only three. Two of the three patients were clinically and biochemically hypothyroid and showed a delayed recovery of normal H.P.T. function after lithium was stopped. There were no significant differences in thyroid hormone or basal TSH levels between the euthyroid lithium-treated.
摘要
对17例服用维持剂量碳酸锂平均21个月（范围1 - 67个月）的患者进行了下丘脑 - 垂体 - 甲状腺（H.P.T.）功能评估，并对4例患者从开始锂治疗起进行了长达6个月的系列研究。在17例接受维持治疗的患者中，有14例对静脉注射促甲状腺激素释放激素（TRH）的促甲状腺激素（TSH）反应过度，尽管仅3例患者的基础TSH水平升高。这3例患者中有2例临床和生化检查显示甲状腺功能减退，在停用锂后H.P.T.功能恢复正常的时间延迟。甲状腺功能正常的锂治疗患者的甲状腺激素或基础TSH水平无显著差异。
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