Teramoto A, Hirakawa K, Sanno N, Osamura Y
Department of Neurosurgery, Toranomon Hospital, Tokyo, Japan.
Radiology. 1994 Oct;193(1):161-4. doi: 10.1148/radiology.193.1.8090885.
To elucidate the frequency of false-positive results in imaging diagnoses of a functioning pituitary microadenoma, the authors studied various kinds of incidental lesions greater than 2 mm in diameter from a larger series of pituitary glands.
One thousand pituitary glands were studied in a nonselected autopsy series. Most causes of death were acute diseases or accidents. Each gland was fixed in 10% formalin and was then cut horizontally into three or four pieces, which were prepared for usual light microscopy.
Of 178 glands found to have incidental lesions, 61 (34%) lesions were larger than 2 mm. Included were adenomas and hyperplasias (n = 20), Rathke cysts (n = 37), infarctions (n = 2), and hemorrhages (n = 2). Seventeen (74%) of 23 laterally localized lesions were adenomas, and 33 (87%) of 38 medially situated lesions were Rathke cleft cysts. These lesions were found in 5.8%-8.3% of subjects in every generation aged 30 years or older.
Incidental lesions should be considered a cause of false-positive findings (6.1%) when an imaging diagnosis is made of a functioning pituitary microadenoma.
为阐明垂体微腺瘤功能成像诊断中假阳性结果的发生率，作者从大量垂体中研究了各种直径大于2mm的偶然病变。
在一个非选择性尸检系列中研究了1000个垂体。大多数死亡原因是急性疾病或事故。每个垂体用10%福尔马林固定，然后水平切成三或四块，准备进行常规光学显微镜检查。
在178个发现有偶然病变的垂体中，61个（34%）病变大于2mm。包括腺瘤和增生（n = 20）、拉克囊肿（n = 37）、梗死（n = 2）和出血（n = 2）。23个外侧定位病变中有17个（74%）是腺瘤，38个内侧病变中有33个（87%）是拉克裂囊肿。在每一代30岁及以上的受试者中，这些病变的发生率为5.8% - 8.3%。
当对垂体微腺瘤进行功能成像诊断时，偶然病变应被视为假阳性结果的一个原因（6.1%）。
