Hashimoto H, Nishimura Y, Dong R P, Kimura A, Sasazuki T, Yamanaka K, Tokano Y, Murashima A, Kabasawa K, Hirose S
Department of Internal Medicine and Rheumatology, Jutendo University, Tokyo, Japan.
Scand J Rheumatol. 1994;23(4):191-6. doi: 10.3109/03009749409103059.
To determine the association of HLA antigens with SLE and the clinical findings of the disease, HLA antigens were tested in 58 Japanese patients with SLE, who fulfilled the ARA diagnostic criteria, along with 97 normal controls. HLA class I and II antigens were typed serologically using the antisera provided by the 11th HLA Workshop. Among the HLA class II antigens, further DRB, DQ and DP alleles were defined by DNA typing using the PCR/SSOP method. There were significantly more SLE patients with HLA-B39, DRB11501, DRB50101 and DQB10602 than normal controls. This result suggested that the haplotype of HLA-DRB11501-DRB50101-DQA10102-DQB1*0602 consists of the SLE-associated MHC markers in Japan. There were some positive and negative associations between the HLA antigens and clinical or serological findings in SLE. There is a possibility that some HLA alleles might be related to the clinical and/or serological subsets of SLE.
为确定HLA抗原与系统性红斑狼疮（SLE）的关联以及该疾病的临床特征，对58例符合美国风湿病学会（ARA）诊断标准的日本SLE患者以及97名正常对照者进行了HLA抗原检测。使用第11届HLA研讨会提供的抗血清通过血清学方法对HLAⅠ类和Ⅱ类抗原进行分型。在HLAⅡ类抗原中，进一步采用聚合酶链反应/序列特异性寡核苷酸探针（PCR/SSOP）方法通过DNA分型确定DRB、DQ和DP等位基因。携带HLA - B39、DRB11501、DRB50101和DQB10602的SLE患者显著多于正常对照者。这一结果表明，在日本，HLA - DRB11501 - DRB50101 - DQA10102 - DQB1*0602单倍型构成了与SLE相关的主要组织相容性复合体（MHC）标记。HLA抗原与SLE的临床或血清学特征之间存在一些正相关和负相关。某些HLA等位基因有可能与SLE的临床和/或血清学子集相关。
