Tasker R R, Gentili F, Sogabe K, Shanlin M, Hawrylyshyn P
Can J Neurol Sci. 1975 Aug;2(3):303-13. doi: 10.1017/s0317167100020400.
Decorticate spasticity in the squirrel monkey was chosen as a convenient laboratory model of spasticity capable of quantitative assessment upon which to evaluate various currently popular clinical spasmolytic measures. The effects of a wide variety of cortical lesions were studied involving primary and supplementary motor, premotor and parietal cortex unilaterally and bilaterally, measuring muscle tone with the evoked integrated E.M.G. technique. Measurable spasticity resulted only if primary motor cortex was ablated bilaterally usually but not always preferentially involving biceps brachii and quadriceps. Resulting postures were variable offering no justification for the term "decorticate posture". The integrated evoked E.M.G. was proportional to rate of stretch and chiefly phasic in type as in hemiplegic man. Stereotactic dentatectomy resulted in profound ipsilateral reduction in this spasticity, but was without effect in intercollicular or anemic decerebrate cats. The mechanism of the spasticity and of the cerebellar effects are discussed.
松鼠猴的去皮质强直被选为一种方便的痉挛实验室模型，能够进行定量评估，以此来评价当前各种流行的临床解痉措施。研究了多种皮质损伤的影响，包括单侧和双侧的初级运动皮层、辅助运动皮层、运动前区皮层和顶叶皮层，采用诱发肌电图综合技术测量肌张力。只有在双侧切除初级运动皮层时，通常但并非总是优先累及肱二头肌和股四头肌，才会产生可测量的痉挛。由此产生的姿势各不相同，因此“去皮质姿势”这一术语没有依据。诱发肌电图综合信号与拉伸速率成正比，且主要为相位型，与偏瘫患者相同。立体定向齿状核切除术可使这种痉挛在同侧显著减轻，但对中脑间或贫血去大脑猫无效。文中讨论了痉挛的机制以及小脑的作用。
