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[四氯-2,3,7,8-二苯并对二噁英和四溴-2,3,7,8-二苯并对二噁英对大鼠生化作用的相似性]

[Similarities in the biochemical effects of tetrachloro 2,3,7,8 dibenzo-p-dioxin and tetrabromo-2,3,7,8 dibenzo-p-dioxin on rats].

作者信息

Saint-Ruf G, Hien D P

出版信息

C R Acad Hebd Seances Acad Sci D. 1975 Jun 16;280(23):2709-11.

PMID:809157
Abstract

Screening tests for the study of carcinogenic compounds showed that 2,3,7,8-tetrabromodibenzo-p-dioxin was at least as active as 2,3,7,8-tetrachlorodibenzo-p-dioxin in regard to its effect on the in vivo synthesis of zoxanzolamine hydroxylase and on the arginase activity of the liver. The biological properties of these compounds seem to be due to the symmetry of their m molecular structure.

摘要

用于研究致癌化合物的筛选试验表明,就其对体内唑烷醇胺羟化酶合成及肝脏精氨酸酶活性的影响而言,2,3,7,8 - 四溴二苯并 - p - 二恶英的活性至少与2,3,7,8 - 四氯二苯并 - p - 二恶英相当。这些化合物的生物学特性似乎归因于其分子结构的对称性。

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[Similarities in the biochemical effects of tetrachloro 2,3,7,8 dibenzo-p-dioxin and tetrabromo-2,3,7,8 dibenzo-p-dioxin on rats].[四氯-2,3,7,8-二苯并对二噁英和四溴-2,3,7,8-二苯并对二噁英对大鼠生化作用的相似性]
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