[氮芥对氚标记胸腺嘧啶核苷掺入鸡胚肢芽的影响。放射自显影研究]
[The effect of nitrogen mustard on the incorporation of tritiated thymidine into chick embryo limb buds. Autoradiographic study].
作者信息
Salzgeber B
出版信息
C R Acad Hebd Seances Acad Sci D. 1975 Feb 17;280(7):911-4.
PMID:809176
Abstract
Tritiated thymidine labelling has been performed during the 24 hours following the treatment of chick embryos with nitrogen mustard. The rate of incorporation into nuclei of control and treated limb buds varied with the stage of the embryo. In the case of the nitrogen mustard-treated limb buds, a marked inhibition of the incorporation has been observed in the mesenchyme and the apical cap. However, 18 and 24 hours after treatment, the rate of labelling in the apical cap was the same as that in the control.
摘要
在用氮芥处理鸡胚后的24小时内进行了氚标记胸腺嘧啶核苷实验。对照和处理后的肢芽细胞核的掺入率随胚胎发育阶段而变化。在用氮芥处理的肢芽中，已观察到间充质和顶帽中的掺入受到明显抑制。然而，处理后18小时和24小时，顶帽中的标记率与对照相同。
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