Martínez-Frías M L
Departamento de Farmacología, Facultad de Medicina, Universidad Complutense, Madrid, Spain.
Am J Med Genet. 1994 Jun 1;51(2):108-13. doi: 10.1002/ajmg.1320510206.
Using data from the Spanish Collaborative Study of Congenital Malformations (ECEMC), consisting of 19,039 consecutive malformed infants of unselected pregnancies, we have analyzed the relationship between nongestational maternal diabetes and different groups of congenital anomalies. The total sample of malformed babies was separated into two groups: children of nongestational diabetic mothers, and those of nondiabetic women. Analysis of the proportion of children identified in each group with different types of anomalies allows us to demonstrate that the most characteristic group of congenital anomalies observed in the children of diabetic women belongs to the caudal dysgenesis complex, while congenital heart defects are the most frequent malformations in these children. On the other hand, these children also present a multiple congenital anomalies (MCA) pattern more frequently than those of nondiabetic women. From this study it is also clear that the proportion of blastogenic malformations is higher in the offspring of diabetic mothers.
利用西班牙先天性畸形协作研究（ECEMC）的数据，该研究涵盖了19039例未经选择的妊娠中连续出生的畸形婴儿，我们分析了非妊娠期母亲糖尿病与不同类型先天性异常之间的关系。畸形婴儿的总样本被分为两组：非妊娠期糖尿病母亲的孩子和非糖尿病女性的孩子。对每组中患有不同类型异常的儿童比例进行分析，使我们能够证明，在糖尿病女性的孩子中观察到的最具特征性的先天性异常组属于尾部发育不全综合征，而先天性心脏缺陷是这些孩子中最常见的畸形。另一方面，与非糖尿病女性的孩子相比，这些孩子也更频繁地出现多重先天性异常（MCA）模式。从这项研究中还可以清楚地看出，糖尿病母亲后代中致突变性畸形的比例更高。
