Bernard F, Louvard V, Cressy M L, Tanguy M, Mallédant Y
Service d'Anesthésie-Réanimation Chirurgicale, Hôpital Pontchaillou, Rennes.
Ann Fr Anesth Reanim. 1994;13(1):2-5. doi: 10.1016/s0750-7658(94)80179-7.
In pregnant women at term, the oxygen reserve is decreased while the oxygen consumption is increased, carrying the risk of hypoxaemia during periods of apnea. Moreover, intubation of the trachea can be difficult. Therefore preoxygenation is of particular importance. The conventional method of preoxygenation consists in a 3-5 min breathing of 100% O2. However, in some obstetric emergencies, there may not be an adequate delay of time available for this technique. Recently, 4 maximally deep inspirations were demonstrated to be as effective as a 5-min inhalation of 100% O2 for preoxygenation. To determine whether these two techniques were equivalent before induction of a general anaesthesia for Caesarean section, 27 pregnant women at term (ASA 1 or 2) were studied. Following premedication with atropin sulfate (0.5 mg), the patients were randomly allocated into two groups. Group A (n = 12) was denitrogenated with 100% O2 for 4 min and group B (n = 15) with 4 maximally deep inspirations of 100% O2 within 30 s. Oxygen was administered at a flow rate of 10 L.min-1 via a non rebreathing anaesthesia system and a tight fitting face mask. Arterial saturation was assessed by pulse oximetry. General anaesthesia was induced with thiopentone (7 mg.kg-1) and succinylcholine (1.5 mg.kg-1). The trachea was intubated without previous ventilation and the delay required for the SpO2 to decrease to 93% was measured. This time was 137.9 +/- 79.2 s (extremes 85-320) in group A and 144.5 +/- 57.3 s (extremes 60-285) in group B respectively. These times were not significantly different.(ABSTRACT TRUNCATED AT 250 WORDS)
足月孕妇的氧储备减少而氧消耗增加,存在呼吸暂停期间低氧血症的风险。此外,气管插管可能困难。因此,预给氧尤为重要。传统的预给氧方法是让患者呼吸100%氧气3 - 5分钟。然而,在一些产科紧急情况下,可能没有足够的时间采用这种技术。最近,研究表明4次最大深度吸气在预给氧方面与吸入100%氧气5分钟同样有效。为确定在剖宫产全身麻醉诱导前这两种技术是否等效,对27名足月孕妇(ASA 1或2级)进行了研究。在给予硫酸阿托品(0.5毫克)进行术前用药后,将患者随机分为两组。A组(n = 12)用100%氧气去氮4分钟,B组(n = 15)在30秒内进行4次最大深度的100%氧气吸气。通过非重复呼吸麻醉系统和紧密贴合的面罩以10升/分钟的流速给予氧气。通过脉搏血氧饱和度仪评估动脉饱和度。用硫喷妥钠(7毫克/千克)和琥珀酰胆碱(1.5毫克/千克)诱导全身麻醉。在未预先通气的情况下进行气管插管,并测量SpO2降至93%所需的时间。A组的这个时间分别为137.9±79.2秒(范围85 - 320秒),B组为144.5±57.3秒(范围60 - 285秒)。这些时间没有显著差异。(摘要截短于250字)