Hermans J, Schmitz A, Merlo P, Bodart F, Beauduin M
Service d'Oncologie et Médecine Nucléaire, Hôpital de Jolimont, Haine-Saint-Paul, Belgique.
Ann Endocrinol (Paris). 1993;54(4):248-54.
The merits of Thallium 201 radionuclide scanning of the thyroid mentioned as soon as 1976 by PALERMO have been confirmed in the 16 last studies published in the international literature. Over 1601 examinations, authors showed that any cold nodule (Tc 99 m or I 123) which preferentially fixes Thallium 201 as compared to surround thyroid tissue must be operated since some of them are thyroid cancer carriers, some others are carriers of a traditional follicular adenoma or Hurthle-cell adenoma, or a follicular adenoma associated with varied cell atypisms which make difficult the diagnosis between benign and malignant nodules. The analysis of the results published show a 91.3% sensitivity of this diagnosis test, all analysis methods being considered. In case of negative test, it allows eliminating the cancer risk by more than 97% (negative predictive value). Such an examination--as opposed to a cytology test on the isolated nodule only--is valid for any type of nodule, being isolated, multiple or a multinodular goitre where the degeneration risk is close to, or even higher than, that of isolated nodules (4, 22).
1976年帕莱莫首次提及的甲状腺201铊放射性核素扫描的优点，在国际文献中发表的最近16项研究中得到了证实。在超过1601次检查中，作者表明，与周围甲状腺组织相比，任何优先摄取201铊的冷结节（锝99m或碘123）都必须进行手术，因为其中一些是甲状腺癌携带者，另一些是传统滤泡性腺瘤或许特莱细胞腺瘤的携带者，或者是伴有各种细胞异型性的滤泡性腺瘤，这使得良性和恶性结节之间的诊断变得困难。对已发表结果的分析表明，考虑到所有分析方法，该诊断试验的敏感性为91.3%。在检测结果为阴性的情况下，它可以将癌症风险排除97%以上（阴性预测值）。与仅对孤立结节进行细胞学检查不同，这种检查对任何类型的结节都有效，无论是孤立结节、多发结节还是多结节性甲状腺肿，其退变风险接近甚至高于孤立结节（4, 22）。
