Kitano H, Matsuda M
Department of Neurosurgery, Shiga University of Medical Science.
Nihon Geka Hokan. 1993 Nov 1;62(6):287-93.
We studied the effect of high dose nicardipine in patients with ruptured cerebral aneurysm. Seventeen patients were treated with intravenous infusion of nicardipine, 23.0-124.4 mg/day, for 15 days, which was started within 72 hours after onset of subarachnoid hemorrhage (SAH). Aneurysmal neck was clipped within 96 hours after SAH. Five patients were excluded because of discontinuation of treatment due to hypotension and intra- or postoperative complication. Among the 12 patients, symptomatic vasospasm was observed in 6, and one of them had a permanent deficit. Severe angiographic vasospasm was observed in 3 patients, but two of them did not show symptomatic vasospasm. From this study we can't draw any conclusion about effect of nicardipine on prevention of symptomatic and angiographic vasospasm after SAH, because of small number of cases.
我们研究了大剂量尼卡地平对破裂脑动脉瘤患者的影响。17例患者静脉输注尼卡地平，剂量为23.0 - 124.4毫克/天，持续15天，在蛛网膜下腔出血（SAH）发病后72小时内开始给药。SAH后96小时内夹闭动脉瘤颈。5例患者因低血压及术中或术后并发症而停止治疗被排除。在这12例患者中，6例出现症状性血管痉挛，其中1例有永久性神经功能缺损。3例患者出现严重血管造影血管痉挛，但其中2例未出现症状性血管痉挛。由于病例数较少，本研究无法就尼卡地平对SAH后预防症状性和血管造影血管痉挛的效果得出任何结论。
