Joh T H, Weiser M
Laboratory of Molecular Neurobiology, Cornell University Medical College, W. M. Burke Medical Research Institute, White Plains, New York 10605.
Adv Neurol. 1993;60:316-20.
We summarized here two distinctively interesting observations made in the DA neuronal circuitry implicated in Parkinson's disease. When a micro-knife lesion transecting the MFB was placed rostral to the SNc, the following two molecular events were observed. (i) There is a sequential gene expression of Fos, an immediate early gene, in the postsynaptic, presynaptic, and other related neurons in this circuitry. Interestingly, an induction of Fos was never demonstrated in the SNc at any time. (ii) In specific related neuronal populations, the increase in Fos was followed by the induction of the gene for the resident neurotransmitter synthesizing enzymes. The induction of these genes for Fos and neurotransmitter enzymes most likely indicates the distinctive activity of these neurons after the injury of the DA neurons in the SNc. Although these results are preliminary, the present results contribute to the understanding of the molecular processes in the neuronal circuitry implicated in PD.
我们在此总结了在帕金森病相关的多巴胺能神经元回路中所做的两项特别有趣的观察结果。当一把微刀损伤横断黑质纹状体束并置于黑质致密部的嘴侧时，观察到以下两个分子事件。（i）在该回路的突触后、突触前及其他相关神经元中，即早基因Fos呈序贯性基因表达。有趣的是，在任何时候黑质致密部都从未显示出Fos的诱导表达。（ii）在特定的相关神经元群体中，Fos增加后紧接着诱导出驻留神经递质合成酶的基因。Fos和神经递质酶这些基因的诱导最有可能表明黑质致密部多巴胺能神经元损伤后这些神经元的独特活性。尽管这些结果是初步的，但目前的结果有助于理解帕金森病相关神经元回路中的分子过程。
