Marvizón J C, Baudry M
Neurobiology Program, University of Southern California, Los Angeles 90089-2520.
Eur J Pharmacol. 1993 Jan 4;244(1):103-4. doi: 10.1016/0922-4106(93)90065-h.
Stimulation by spermine of [3H]MK-801 binding to N-methyl-D-aspartate (NMDA) receptors was additive with the effect of glutamate and glycine, but was completely abolished by the glutamate antagonist 3-(carboxypiperazin-4-yl)propyl-1-phosphonate (CPP, 10 microM) or the glycine antagonist 7-chlorokynurenate (10 microM). Blockade by 7-chlorokynurenate could be overcome in the presence of glutamate, whereas blockade by CPP was unaffected by glycine. Therefore, NMDA receptors can be activated by glutamate and spermine but not by glycine and spermine.
精胺对[3H]MK-801与N-甲基-D-天冬氨酸（NMDA）受体结合的刺激作用与谷氨酸和甘氨酸的作用呈相加性，但完全被谷氨酸拮抗剂3-（羧基哌嗪-4-基）丙基-1-膦酸（CPP，10微摩尔）或甘氨酸拮抗剂7-氯犬尿氨酸（10微摩尔）所消除。在存在谷氨酸的情况下，7-氯犬尿氨酸的阻断作用可被克服，而CPP的阻断作用不受甘氨酸影响。因此，NMDA受体可被谷氨酸和精胺激活，但不能被甘氨酸和精胺激活。
