L-三碘甲状腺原氨酸对胞质3-羟基-3-甲基戊二酰辅酶A合酶mRNA水平的调节
Regulation of cytosolic 3-hydroxy-3-methylglutaryl-CoA synthase mRNA levels by L-tri-iodothyronine.
作者信息
Royo T, Haro D, Hegardt F G
机构信息
Unit of Biochemistry, University of Barcelona, School of Pharmacy, Spain.
出版信息
Biochem J. 1993 Jan 15;289 ( Pt 2)(Pt 2):557-60. doi: 10.1042/bj2890557.
Abstract
In hypophysectomized and thyroidectomized rats, cytosolic 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase activity, immunoreactive protein and mRNA levels were all considerably decreased. Administration of L-tri-iodothyronine (T3) resulted in a large increase in all three in hypophysectomized rats and in only a 2-fold increase (reaching the values of control rats) in thyroidectomized rats.
摘要
在垂体切除和甲状腺切除的大鼠中，胞质3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）合酶活性、免疫反应性蛋白和mRNA水平均显著降低。给予L-三碘甲状腺原氨酸（T3）后，垂体切除大鼠的这三项指标均大幅升高，而甲状腺切除大鼠仅升高两倍（达到对照大鼠的值）。
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