Corey L, Coombs R W
Department of Laboratory Medicine, University of Washington, Seattle.
Clin Infect Dis. 1993 Feb;16 Suppl 1:S2-6. doi: 10.1093/clinids/16.supplement_1.s2.
Although AIDS is a complex clinical disease with diverse manifestations, infection with human immunodeficiency virus (HIV) per se is almost entirely subclinical. The evaluation of antiretroviral agents is difficult because of the lack of a direct clinical relationship between the replication of HIV and the subsequent development of nonviral opportunistic infection. Thus surrogate markers, especially the results obtained in laboratory assays of the inhibition of replicating virus in vivo, have emerged as important factors in the evaluation of a drug's in vivo antiviral efficacy.
尽管艾滋病是一种临床表现复杂多样的疾病，但人体免疫缺陷病毒（HIV）感染本身几乎完全没有临床症状。由于HIV复制与随后非病毒机会性感染的发生之间缺乏直接的临床关联，对抗逆转录病毒药物的评估存在困难。因此，替代标志物，尤其是体内抑制病毒复制的实验室检测结果，已成为评估药物体内抗病毒疗效的重要因素。
