Holle G E, Stiegelmeier M, Riedel J, Ringel R, Siewert R, Eisenmenger W, Holle F
Walther Straub Institute, Ludwig Maximilians University, Department of Surgery, Munich, Germany.
Surg Gynecol Obstet. 1993 Jan;176(1):65-72.
Examination of gastrin-immunoreactive G-cells, somatostatin-immunoreactive D-cells, enterochromaffin cells and 5-hydroxytryptamine-immunoreactive (5-HT-immunoreactive) cells of the completely mapped histologic antrum (70 to 100 tissue blocks) was done in 20 normal stomachs of persons between 17 and 94 years of age (from forensic autopsy). Results were compared with those of nine patients between 48 and 76 years of age with total gastrectomy for carcinoma of the proximal part of the stomach. Cell counts and morphometric examinations were performed. Results were summarized for the proximal (I), middle (II) and distal (III) one-third of the antrum and for the major (A) and minor (B) curvature side. In normal stomachs, the G-cell count was 2.52 percent of the total gland cell count in AI; 4.25 percent in AII and 4.77 percent in AIII. In BI, the numbers were 2.5 percent, in BII, 3.73 percent and 4.06 percent in BIII. The D-cell count was 0.47 percent in AI, 0.62 percent in AII and 0.58 percent in AIII. The numbers were 0.44 percent in BI, 0.51 percent in BII and 0.51 percent in BIII. In the antrum of the stomach with carcinoma, the G-cells revealed a non-significant 20 to 70 percent lower cell count, while the D-cell count was reduced insignificantly by as much as 35 percent in all areas. The 5-HT-immunoreactive cell count in normal stomachs is 0.25 percent in AI of the total gland cells, 0.32 percent in AII and 0.39 percent in AIII. In B, it shows numerically no difference to that of A. Contrary to the cell count in normal stomachs, the carcinoma antrum revealed a 200 to 400 percent increase in 5-HT-immunoreactive cell count, highly significant in every area of the antrum. Because 5-HT is known as a growth stimulant, especially for tumors, an increase in 5-HT-immunoreactive cells may be a factor that contributes to the initial histologic changes observed during the early phase of gastric tumor.
对20例年龄在17至94岁之间（来自法医尸检）的正常胃的完全映射组织学胃窦（70至100个组织块）中的胃泌素免疫反应性G细胞、生长抑素免疫反应性D细胞、肠嗜铬细胞和5-羟色胺免疫反应性（5-HT免疫反应性）细胞进行了检查。将结果与9例年龄在48至76岁之间因胃近端癌行全胃切除术的患者的结果进行了比较。进行了细胞计数和形态计量学检查。对胃窦的近端（I）、中间（II）和远端（III）三分之一以及大弯（A）和小弯（B）侧的结果进行了总结。在正常胃中，G细胞计数在胃窦近端三分之一（AI）中占总腺细胞计数的2.52%；在中间三分之一（AII）中占4.25%，在远端三分之一（AIII）中占4.77%。在小弯侧的近端（BI），该数字为2.5%，在中间（BII）为3.73%，在远端（BIII）为4.06%。D细胞计数在AI中为0.47%，在AII中为0.62%，在AIII中为0.58%。在BI中为0.44%，在BII中为0.51%，在BIII中为0.51%。在胃癌患者的胃窦中，G细胞计数降低了20%至70%，差异无统计学意义，而D细胞计数在所有区域均无明显降低，最多降低35%。正常胃中5-HT免疫反应性细胞计数在胃窦近端三分之一（AI）中占总腺细胞的0.25%，在中间三分之一（AII）中占0.32%，在远端三分之一（AIII）中占0.39%。在小弯侧，其数值与大弯侧无差异。与正常胃中的细胞计数相反，癌性胃窦中5-HT免疫反应性细胞计数增加了200%至400%，在胃窦的每个区域均具有高度统计学意义。由于5-HT被认为是一种生长刺激剂，尤其是对肿瘤而言，5-HT免疫反应性细胞的增加可能是导致胃癌早期观察到的初始组织学变化的一个因素。
