Gainer J L, Briscoe M G, Holloway B R
ICI Pharmaceuticals, Mereside, Macclesfield, Cheshire, England.
Experientia. 1993 Jan 15;49(1):68-72. doi: 10.1007/BF01928793.
The thermogenic action of beta-adrenoceptor agonists may be due, in part, to increased metabolism in skeletal muscle. Previous results suggest that vasoconstriction is also necessary, and that the effect can be blocked by vasodilators. Both noradrenaline and the beta-3 agonist, ICI D7114, were studied using two dog hindlimb protocols. During constant perfusion conditions, ICI D7114 caused a significant increase in hindlimb oxygen consumption although it is a vasodilator. Noradrenaline resulted in a smaller rise in oxygen consumption, and produced a marked vasoconstriction. Both noradrenaline and ICI D7114 resulted in decreased oxygen consumption when the blood flow was allowed to vary in response to the drug treatment. The results suggest that changes in tissue oxygen consumption caused by beta-agonists are not related to vasomotion.
β-肾上腺素能受体激动剂的产热作用可能部分归因于骨骼肌代谢的增加。先前的结果表明血管收缩也是必要的，并且这种作用可被血管扩张剂阻断。使用两种犬后肢实验方案对去甲肾上腺素和β-3激动剂ICI D7114进行了研究。在持续灌注条件下，尽管ICI D7114是一种血管扩张剂，但它仍使后肢耗氧量显著增加。去甲肾上腺素导致的耗氧量升高幅度较小，并引起明显的血管收缩。当血流根据药物治疗而变化时，去甲肾上腺素和ICI D7114均导致耗氧量降低。结果表明，β-激动剂引起的组织耗氧量变化与血管运动无关。
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