不同物种髓鞘碱性蛋白在Lewis大鼠中效力差异的分子基础。
Molecular bases for the difference in the potency of myelin basic protein from different species in Lewis rats.
作者信息
Hashim G A
出版信息
Adv Exp Med Biol. 1978;100:289-301. doi: 10.1007/978-1-4684-2514-7_21.
The results of this study define the chemical bases for the difference in the encephalitogenic potency reported for the bovine and guinea pig myelin basic proteins. Studies with synthetic peptides showed that the sequence of peptide S53, H-Ser-Gln-Arg-Ser-Gln-Asp-Glu-Asn-OH, which is native to the guinea pig basic protein, is the minimum amino acid sequence necessary for inducing EAE in Lewis rats. The results of this study further showed that specific sequence modifications rendered the native bovine sequence highly encephalitogenic.
本研究结果确定了牛和豚鼠髓鞘碱性蛋白在致脑炎性效力方面存在差异的化学基础。对合成肽的研究表明，豚鼠碱性蛋白中的肽段S53（H-Ser-Gln-Arg-Ser-Gln-Asp-Glu-Asn-OH）序列是在Lewis大鼠中诱导实验性自身免疫性脑脊髓炎（EAE）所需的最小氨基酸序列。本研究结果还表明，特定的序列修饰使天然牛序列具有高度致脑炎性。
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