Paolicchi A, Chieli E, Rugiu E S, Tongiani R
Dipartimento di Biomedicina, Università di Pisa, Italy.
Life Sci. 1993;52(7):631-7. doi: 10.1016/0024-3205(93)90454-b.
Gamma-glutamyltransferase (GGT) inducibility by dexamethasone (DEX) in rat liver decreased by about 95% within the first 14 days of life, while the liver content of cytochrome P-450 (P-450) increased by about 500%. Cobaltic Protoporphyrin IX (CPP), given on the 9th day of life, caused a temporary depression of the P-450 liver content, with maximal effects 3 and 4 days after the administration of CPP. GGT induction by DEX was significantly higher in CPP-treated rats than in untreated ones, with maximum induction coinciding with the maximal decrease of P-450. These effects were CPP dose-dependent.
出生后前14天内，大鼠肝脏中地塞米松（DEX）诱导γ-谷氨酰转移酶（GGT）的能力下降了约95%，而细胞色素P-450（P-450）的肝脏含量增加了约500%。出生第9天给予钴原卟啉IX（CPP）会导致P-450肝脏含量暂时降低，给药后3天和4天效果最为明显。与未治疗的大鼠相比，CPP治疗的大鼠中DEX诱导GGT的能力显著更高，最大诱导与P-450的最大降低同时出现。这些效应呈CPP剂量依赖性。
