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睡眠剥夺中多巴胺与阿片类物质的相互作用。

Dopamine and opioids interactions in sleep deprivation.

作者信息

Fadda P, Martellotta M C, Gessa G L, Fratta W

机构信息

B.B. Brodie Department of Neuroscience, University of Cagliari, Italy.

出版信息

Prog Neuropsychopharmacol Biol Psychiatry. 1993 Mar;17(2):269-78. doi: 10.1016/0278-5846(93)90047-v.

Abstract
  1. Sleep deprivation induced by the platform technique is considered to be a heavy stressful situation in rats. At the end of the sleep deprivation period (72 hrs) the rat displayed particular behavior characterized by wakefulness, a high degree of motor and exploratory activity, increased alertness and reactivity to environmental stimuli. 2. Our results indicate that this behavior is potently antagonized by the administration of D1 antagonist SCH 23390 and by the opioid antagonist naloxone. 3. We also show that concomitantly to this behavior, an increased number of D1 receptors associated with an increased dopamine-stimulated adenylate cyclase activity is present in the limbic system but not in the striatum of these animals. On the contrary, a decreased Bmax of mu and delta opioid receptors was found in the same brain areas. 4. These data suggest an active role of limbic dopamine and opioid system in the generation of arousal and insomnia related to sleep deprivation-induced stress.
摘要
  1. 平台技术诱导的睡眠剥夺被认为是大鼠面临的一种高度应激状态。在睡眠剥夺期结束时(72小时),大鼠表现出特定行为,其特征为清醒、高度的运动和探索活动、对环境刺激的警觉性和反应性增加。2. 我们的结果表明,给予D1拮抗剂SCH 23390和阿片类拮抗剂纳洛酮可有效对抗这种行为。3. 我们还表明,与这种行为同时出现的是,这些动物的边缘系统中与多巴胺刺激的腺苷酸环化酶活性增加相关的D1受体数量增多,但纹状体中没有。相反,在相同脑区发现μ和δ阿片受体的Bmax降低。4. 这些数据表明边缘多巴胺和阿片系统在与睡眠剥夺诱导的应激相关的觉醒和失眠的产生中发挥积极作用。

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