Paulson G W
Ohio State University, Columbus.
Geriatrics. 1993 Feb;48(2):30-4, 39-40.
Initial therapy of a patient newly diagnosed with Parkinson's disease depends on a variety of presenting symptoms and therefore must be individualized. Some patients do not initially require any therapy or can be managed with small doses of antidepressants. Anticholinergics are useful initial drugs for some patients, particularly when tremor is a presenting symptom. For rigidity, levodopa is the drug most likely to be helpful. Dopamine agonists and amantadine may be used initially, but more often are used as adjunct therapy later in the course of the disease. Selegiline probably should be considered for all newly diagnosed patients, because it may have the potential to slow disease progression.
新诊断帕金森病患者的初始治疗取决于多种呈现出的症状，因此必须个体化。一些患者最初不需要任何治疗，或者可以用小剂量抗抑郁药进行处理。抗胆碱能药物对一些患者是有用的初始药物，尤其是当震颤是呈现出的症状时。对于僵硬，左旋多巴是最可能有帮助的药物。多巴胺激动剂和金刚烷胺可在初始时使用，但在疾病进程后期更常作为辅助治疗使用。对于所有新诊断的患者可能都应考虑使用司来吉兰，因为它可能有减缓疾病进展的潜力。
