利用增殖细胞核抗原免疫反应性鉴别水肿性流产与部分性葡萄胎。
Use of proliferation cell nuclear antigen immunoreactivity for distinguishing hydropic abortions from partial hydatidiform moles.
作者信息
Suresh U R, Hale R J, Fox H, Buckley C H
机构信息
Department of Pathological Sciences, University of Manchester.
出版信息
J Clin Pathol. 1993 Jan;46(1):48-50. doi: 10.1136/jcp.46.1.48.
AIMS
To determine whether the expression of proliferating cell nuclear antigen (PCNA) in villous cytotrophoblast could distinguish between placental tissue from a hydropic abortion and that from a partial hydatidiform mole.
METHODS
Tissue from 18 partial hydatidiform moles, 15 hydropic abortions, five normal first trimester placentas and five normal full term placentas were immunostained for expression of PCNA, using the monoclonal antibody PC10.
RESULTS
PCNA immunoreactivity was very much higher in the cytotrophoblast of normal first trimester placentas than in normal term placentas. Villous tissue from partial hydatidiform moles showed, on average, less immunoreactivity for PCNA than did villous tissue from hydropic abortions.
CONCLUSIONS
Immunostaining for PCNA is of no value for differentiating between partial hydatidiform moles and hydropic abortions. The findings indicate that trophoblastic proliferation or hyperplasia is not a feature of partial hydatidiform moles.
目的
确定绒毛细胞滋养层中增殖细胞核抗原（PCNA）的表达是否能够区分稽留流产的胎盘组织和部分性葡萄胎的胎盘组织。
方法
采用单克隆抗体PC10对18例部分性葡萄胎、15例稽留流产、5例正常早孕胎盘和5例正常足月胎盘的组织进行PCNA表达的免疫染色。
结果
正常早孕胎盘的细胞滋养层中PCNA免疫反应性远高于正常足月胎盘。部分性葡萄胎的绒毛组织平均显示出比稽留流产的绒毛组织更低的PCNA免疫反应性。
结论
PCNA免疫染色对于区分部分性葡萄胎和稽留流产没有价值。研究结果表明滋养层增殖或增生不是部分性葡萄胎的特征。
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