Gorman J M, Mayeux R, Stern Y, Williams J B, Rabkin J, Goetz R R, Ehrhardt A A
HIV Center for Clinical and Behavioral Studies, New York State Psychiatric Institute, NY 10032.
Am J Psychiatry. 1993 Mar;150(3):505-7. doi: 10.1176/ajp.150.3.505.
The authors examined the effects of zidovudine on neuropsychiatric measures, at three assessment points separated by 6 months, in 25 HIV-positive men who took zidovudine for at least 6 months and a comparison group of 25 HIV-positive men with similar CD4+ T cell counts who had never taken zidovudine. Zidovudine had no statistically significant effect except for a slight improvement in Global Assessment of Functioning scale score. In this small group of subjects there was little benefit but also little evidence of CNS toxicity from zidovudine.
作者在三个间隔6个月的评估点，对25名服用齐多夫定至少6个月的HIV阳性男性以及25名CD4 + T细胞计数相似但从未服用过齐多夫定的HIV阳性男性组成的对照组，研究了齐多夫定对神经精神指标的影响。除了功能总体评估量表评分略有改善外，齐多夫定没有统计学上的显著效果。在这一小群受试者中，齐多夫定几乎没有益处，但也几乎没有中枢神经系统毒性的证据。
