Vanhagen P M, Krenning E P, Reubi J C, Mulder A H, Bakker W H, Oei H Y, Löwenberg B, Lamberts S W
Department of Internal Medicine III, University Hospital Rotterdam, The Netherlands.
Br J Haematol. 1993 Jan;83(1):75-9. doi: 10.1111/j.1365-2141.1993.tb04634.x.
Normal as well as activated lymphocytes, macrophages and leukaemic cells have previously been shown by radio receptor analysis to express receptors for somatostatin. An 111In labelled somatostatin analogue was already used successfully in the visualization of a variety of neuro-endocrine tumours. We investigated 10 consecutive patients with malignant lymphomas (Hodgkin's disease and non-Hodgkin's lymphomas). In all patients the lymphoma deposits could be visualized with somatostatin receptor imaging. In four patients additional tumour localizations were observed as compared to the results of combined physical and radiological (CT and ultrasound) examinations. In four cases tissue biopsies were taken and confirmed by autoradiography to be somatostatin receptor positive. These data indicate that malignant lymphomas may express somatostatin receptors in sufficient numbers and density to allow in vivo tumour visualization with a radiolabelled somatostatin analogue.
通过放射受体分析已证实，正常淋巴细胞以及活化的淋巴细胞、巨噬细胞和白血病细胞均表达生长抑素受体。一种铟-111标记的生长抑素类似物已成功用于多种神经内分泌肿瘤的显像。我们对10例连续的恶性淋巴瘤患者（霍奇金病和非霍奇金淋巴瘤）进行了研究。在所有患者中，淋巴瘤病灶均可通过生长抑素受体显像显示出来。与体格检查和放射学检查（CT和超声）联合结果相比，4例患者观察到了额外的肿瘤定位。4例患者进行了组织活检，并通过放射自显影证实为生长抑素受体阳性。这些数据表明，恶性淋巴瘤可能表达足够数量和密度的生长抑素受体，从而能够用放射性标记的生长抑素类似物在体内进行肿瘤显像。
