Bai J P
College of Pharmacy, University of Minnesota, Minneapolis 55455.
Life Sci. 1993;52(11):941-7. doi: 10.1016/0024-3205(93)90529-c.
The distribution profiles of brush border membrane activities of endopeptidase-24.11, angiotensin converting enzyme (ACE), and dipeptidyl peptidase IV (DPP IV) along the rabbit intestine were examined. DPP IV had the lowest activity in the duodenum and much higher in other segments. In those segments, its activities were similar. As regards endopeptidase-24.11 and ACE, the jejunum had the highest activities, followed by the duodenum and the ileum. Activities of these two enzymes were lower in the distal intestine. The decline of ACE activity toward the distal end was more dramatic than that of endopeptidase-24.11 activity. The results suggest that, along the intestine, endopeptidase-24.11 and ACE have similar distribution profiles while DPP IV has a different distribution pattern.
研究了兔肠道中内肽酶-24.11、血管紧张素转换酶（ACE）和二肽基肽酶IV（DPP IV）刷状缘膜活性的分布情况。DPP IV在十二指肠中的活性最低，在其他节段则高得多。在这些节段中，其活性相似。至于内肽酶-24.11和ACE，空肠的活性最高，其次是十二指肠和回肠。这两种酶在远端肠道中的活性较低。ACE活性向远端的下降比内肽酶-24.11活性的下降更为显著。结果表明，在整个肠道中，内肽酶-24.11和ACE具有相似的分布情况，而DPP IV具有不同的分布模式。
