探针BMS1271识别出一个新的多态性位点（D3S1207），并定位于3p26 - pter。

The probe BMS1271 identifies a new polymorphic locus (D3S1207) and maps to 3p26-pter.

作者信息

Heppell-Parton A C, Daly M C, Drabkin H A, Rabbitts P H

机构信息

MRC Clinical Oncology and Radiotherapeutics Unit, MRC Centre, Cambridge, UK.

出版信息

Cytogenet Cell Genet. 1993;63(1):64-5. doi: 10.1159/000133505.

DOI:10.1159/000133505

PMID:8095447

Abstract

We report here the characterization of a new polymorphic locus (D3S1207), shown by fluorescence in situ hybridization to map to 3p26-pter. The distal region of chromosome 3 has been implicated in both von Hippel-Lindau and 3p deletion syndrome, lung, uterine, breast, testicular, and ovarian cancers, renal cell and nasopharyngeal carcinomas, mesotheliomas, and various haematological malignancies, yet relatively few polymorphic marker probes are well mapped within this region. The identification of this new probe will therefore be particularly useful for the study of these diseases.

摘要

我们在此报告一个新的多态性位点（D3S1207）的特征，通过荧光原位杂交显示其定位于3p26 - pter。3号染色体的远端区域与冯·希佩尔 - 林道病和3p缺失综合征、肺癌、子宫癌、乳腺癌、睾丸癌和卵巢癌、肾细胞癌和鼻咽癌、间皮瘤以及各种血液系统恶性肿瘤有关，但该区域内定位良好的多态性标记探针相对较少。因此，这种新探针的鉴定对于这些疾病的研究将特别有用。