Wakasugi M, Wakao R, Tawata M, Gan N, Koizumi K, Onaya T
Third Department of Internal Medicine, University of Yamanashi Medical School, Japan.
Clin Endocrinol (Oxf). 1993 Mar;38(3):283-6. doi: 10.1111/j.1365-2265.1993.tb01007.x.
We assessed the changes of bone mass in patients with hyperthyroidism by measuring bone mineral density using a new method, dual energy X-ray absorptiometry.
The values of bone mineral density in patients with hyperthyroidism were compared with data obtained from the controls, and we assessed the correlation analysis between bone mineral density and several metabolic parameters.
We studied 52 Japanese patients with hyperthyroidism (20 males, 32 females). Healthy normal subjects served to establish the mean bone mineral density in the healthy Japanese population (Shiraki et al. 1991).
Bone mineral density was assessed by the measurement of lumbar vertebrae and femur by dual energy X-ray absorptiometry. The bone mineral density of vertebrae for each patient was calculated as the percentage of the mean value (% bone mineral density) obtained from an age and sex-matched control group. Blood was drawn to measure the levels of serum calcium, phosphorus, creatinine, alkaline phosphatase, free T3, free T4, TSH, TSH receptor antibody, parathyroid hormone, and serum osteocalcin.
The percentage bone mineral density of vertebrae in patients was 92.6 as compared with that of normal controls, and was inversely correlated with serum TSH receptor antibody, osteocalcin, and alkaline phosphatase.
These findings suggest that bone mineral density is decreased in patients with hyperthyroidism and that TSH receptor antibody, osteocalcin, and alkaline phosphatase are sensitive markers of bone metabolism alterations in hyperthyroidism.
我们使用一种新方法——双能X线吸收法测量骨密度，评估甲状腺功能亢进症患者的骨量变化。
将甲状腺功能亢进症患者的骨密度值与对照组的数据进行比较，并评估骨密度与几个代谢参数之间的相关性分析。
我们研究了52例日本甲状腺功能亢进症患者（男性20例，女性32例）。健康正常受试者用于确定健康日本人群的平均骨密度（Shiraki等人，1991年）。
通过双能X线吸收法测量腰椎和股骨来评估骨密度。将每位患者的椎骨骨密度计算为年龄和性别匹配的对照组获得的平均值的百分比（骨密度百分比）。抽取血液测量血清钙、磷、肌酐、碱性磷酸酶、游离T3、游离T4、促甲状腺激素（TSH）、TSH受体抗体、甲状旁腺激素和血清骨钙素的水平。
患者椎骨的骨密度百分比与正常对照组相比为92.6，且与血清TSH受体抗体、骨钙素和碱性磷酸酶呈负相关。
这些发现表明甲状腺功能亢进症患者的骨密度降低，并且TSH受体抗体、骨钙素和碱性磷酸酶是甲状腺功能亢进症骨代谢改变的敏感标志物。
