Carter D A
Neuropeptide Laboratory, National University of Singapore.
Eur J Pharmacol. 1993 Feb 15;244(3):285-91. doi: 10.1016/0922-4106(93)90154-2.
In the rat pineal gland the immediate early genes c-fos and jun-B are co-ordinately induced in vivo following the onset of darkness, and in vitro following treatment with adrenergic drugs. An extensive in vitro analysis of the mechanisms which regulate the induction of these two genes has revealed that, although there are common pathways of control, c-fos and jun-B exhibit differential regulation by adrenoceptor types, second messenger pathways and protein kinase C. The presence of differential intracellular mechanisms of regulation provides precise control over the expression pattern of immediate early genes, a pattern which is crucial for cellular response since the combinatorial actions of the products of these genes are a determinant of target gene activation. The pineal gland is a unique experimental model in which the molecular pharmacology of immediate early gene regulation can be investigated.
在大鼠松果体中，即刻早期基因c-fos和jun-B在体内随着黑暗的开始而协同诱导，在体外经肾上腺素能药物处理后也会被诱导。对调节这两个基因诱导的机制进行的广泛体外分析表明，尽管存在共同的控制途径，但c-fos和jun-B在肾上腺素能受体类型、第二信使途径和蛋白激酶C的作用下表现出差异调节。存在差异的细胞内调节机制可对即刻早期基因的表达模式进行精确控制，这种模式对于细胞反应至关重要，因为这些基因产物的组合作用是靶基因激活的决定因素。松果体是一个独特的实验模型，可用于研究即刻早期基因调节的分子药理学。
