Goossens J F, Manechez D, Pommery N, Formstecher P, Hénichart J P
INSERM U16, Lille, France.
Neuropeptides. 1993 Feb;24(2):99-103. doi: 10.1016/0143-4179(93)90027-8.
Tissue transglutaminase (tTG) activity was used to test the potent regulatory role of vasoactive intestinal peptide (VIP) on Retinoic Acid-induced effect in human neuroblastoma cell line. The comparison between both differentiation and cell death related to tissue transglutaminase was discussed in this model. VIP alone was a potent differentiating agent in SK-N-SH cells but in the presence of retinoic acid (RA), this peptide rather potentiates RA-induced tTG activity which is now considered as an apoptosis marker in neuroblastoma cell line. This paper demonstrated an additional neuromodulator role for VIP.
