多态性主要组织相容性复合体祖传单倍型影响肿瘤坏死因子-α的活性。
Polymorphic MHC ancestral haplotypes affect the activity of tumour necrosis factor-alpha.
作者信息
Abraham L J, French M A, Dawkins R L
机构信息
Department of Clinical Immunology, Royal Perth Hospital, Australia.
出版信息
Clin Exp Immunol. 1993 Apr;92(1):14-8. doi: 10.1111/j.1365-2249.1993.tb05940.x.
Abstract
It remains unclear which MHC loci are involved in susceptibility to autoimmune diseases and immune deficiencies. We have chosen to evaluate whether different alleles of tumour necrosis factor-alpha (TNF-alpha) are important, as TNF has been implicated in the etiology of many immunological disorders. We have shown previously that a restriction fragment length polymorphism in the TNF region correlates with MHC ancestral haplotypes. We therefore examined the effect of ancestral haplotype on the activity of TNF-alpha in culture supernatants of lymphoblastoid cell lines. The results demonstrate that TNF-alpha activity in supernatants of 8.1 (A1, B8, DR3) cell lines was higher than that present in the supernatants from cells homozygous for eight different MHC ancestral haplotypes, and indicate that polymorphisms in TNF-alpha, or in other MHC genes that regulate TNF, may be responsible for the 8.1 phenotype.
摘要
目前尚不清楚哪些主要组织相容性复合体（MHC）基因座与自身免疫性疾病易感性和免疫缺陷有关。我们选择评估肿瘤坏死因子-α（TNF-α）的不同等位基因是否重要，因为TNF已被认为与许多免疫性疾病的病因有关。我们之前已经表明，TNF区域的限制性片段长度多态性与MHC祖传单倍型相关。因此，我们研究了祖传单倍型对淋巴母细胞系培养上清液中TNF-α活性的影响。结果表明，8.1（A1、B8、DR3）细胞系上清液中的TNF-α活性高于八种不同MHC祖传单倍型纯合细胞上清液中的活性，这表明TNF-α或其他调节TNF的MHC基因中的多态性可能是8.1表型的原因。
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