果蝇中枢神经系统中线细胞的发育与功能。
The development and function of the Drosophila CNS midline cells.
作者信息
Nambu J R, Lewis J O, Crews S T
机构信息
Department of Biology, University of California, Los Angeles 90024.
出版信息
Comp Biochem Physiol Comp Physiol. 1993 Mar;104(3):399-409. doi: 10.1016/0300-9629(93)90439-b.
PMID:8097144
Abstract
- The midline cells of the Drosophila embryonic CNS comprise a discrete neuroanatomical structure consisting of a small subset of neurons and glia. 2. Developmental commitment of the CNS midline cells requires the action of dorsal/ventral patterning genes. 3. The single-minded gene encodes a basic-helix-loop-helix transcription factor and acts as a master regulator for the CNS midline lineage. 4. A number of different transcription factors and proteins involved in cell-cell interactions are necessary for the differentiation of midline neurons and glia. 5. CNS midline cells have important functions in the formation of the ventral epidermis and axon commissures.
摘要
- 果蝇胚胎中枢神经系统的中线细胞构成一个离散的神经解剖结构，由一小部分神经元和神经胶质细胞组成。2. 中枢神经系统中线细胞的发育定向需要背/腹模式基因的作用。3. 单-minded基因编码一种碱性螺旋-环-螺旋转录因子，并作为中枢神经系统中线谱系的主要调节因子发挥作用。4. 中线神经元和神经胶质细胞的分化需要多种不同的转录因子和参与细胞间相互作用的蛋白质。5. 中枢神经系统中线细胞在腹侧表皮和轴突连合的形成中具有重要功能。
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