Carson C W, Conn D L, Czaja A J, Wright T L, Brecher M E
Department of Medicine, Mayo Clinic and Foundation, Rochester, MN.
J Rheumatol. 1993 Feb;20(2):304-9.
We tested sera from 56 patients to determine the seroprevalence of antibodies to hepatitis C virus (HCV) in polyarteritis nodosa (PAN), to assess the specificity of these antibodies for hepatitis C virus encoded antigens, and to evaluate the clinical features in patients with HCV infection and PAN. Eleven (20%) were positive for anti-HCV by an enzyme immunoassay. Three (5%) had specific antibodies to HCV encoded antigens detected by recombinant immunoblot assay (RIBA II) and had HCV RNA detected by polymerase chain reaction. Patients with HCV infection were more likely to have liver and skin involvement and a diminished serum complement.
我们检测了56例患者的血清，以确定结节性多动脉炎（PAN）患者中丙型肝炎病毒（HCV）抗体的血清流行率，评估这些抗体对HCV编码抗原的特异性，并评估HCV感染合并PAN患者的临床特征。通过酶免疫测定，11例（20%）抗HCV呈阳性。3例（5%）通过重组免疫印迹法（RIBA II）检测到针对HCV编码抗原的特异性抗体，并通过聚合酶链反应检测到HCV RNA。HCV感染患者更易出现肝脏和皮肤受累以及血清补体降低。
