Russo R, Veschi G, Dellino E, Ciceri R, Iapichino G
Servizio di Anestesia e Rianimazione, IRCCS, Ospedale Maggiore di Milano.
Minerva Anestesiol. 1993 Jan-Feb;59(1-2):35-8.
The authors determined the onset time and the duration of action of neuromuscular blockade by a 100-150 micrograms.kg-1 vecuronium random administration in 30 ASA I and ASA II patients during urological surgery. Neuromuscular blockade was evaluated by the electromyographic response to stimulation of the ulnar nerve train of four. The time from vecuronium administration to complete abolition of twitch response (T1 = 0%) did not change significantly, in spite of 50% increased dose of neuromuscular relaxant. The duration of action of neuromuscular blockade, that is the time from T1 = 0% to T1 = 25%, increased from 38.2 +/- 7.5 min to 52.5 +/- 19.8 min by the increasing of neuromuscular relaxant dose (p < or = 0.018). Vecuronium increased doses did not shorten significantly the onset time.
作者对30例美国麻醉医师协会（ASA）分级为I级和II级的患者在泌尿外科手术期间随机给予100 - 150微克/千克维库溴铵，测定神经肌肉阻滞的起效时间和作用持续时间。通过对尺神经进行四个成串刺激的肌电图反应来评估神经肌肉阻滞。尽管神经肌肉阻滞剂剂量增加了50%，但从给予维库溴铵到抽搐反应完全消失（T1 = 0%）的时间并无显著变化。神经肌肉阻滞的作用持续时间，即从T1 = 0%到T1 = 25%的时间，随着神经肌肉阻滞剂剂量的增加从38.2±7.5分钟延长至52.5±19.8分钟（p≤0.018）。维库溴铵剂量增加并未显著缩短起效时间。
