Mizukami Y, Nonomura A, Michigishi T, Noguchi M, Nakamura S, Hashimoto T
Pathology Section, Kanazawa University Hospital, Japan.
Anticancer Res. 1993 Jan-Feb;13(1):267-71.
Four sorts of tumor proliferation-related markers were studied in 50 papillary carcinomas of the thyroid, and the results were correlated with the histologic subtypes of papillary thyroid carcinoma, which have been shown to be associated with the prognosis of the disease. The mitotic count analyzed by light microscopy, the proliferating cell nuclear antigen (PCNA) and the epidermal growth factor (EGF) expressions by immunohistochemical analysis, and the ploidy status analyzed by DNA flow cytometry were used as the proliferation-related markers in this study. The presence of mitoses, high PCNA score and DNA aneuploidy did not correlate with the histologic subtypes, patient age, sex or the tumor extent. Only EGF expression was significantly correlated with the histologic subtypes. This finding suggests that EGF expression may be the most reliable marker to predict the prognosis of papillary carcinoma of the thyroid.
对50例甲状腺乳头状癌患者研究了四种肿瘤增殖相关标志物，并将结果与甲状腺乳头状癌的组织学亚型相关联，这些组织学亚型已被证明与疾病预后相关。本研究中，通过光学显微镜分析的有丝分裂计数、通过免疫组织化学分析的增殖细胞核抗原（PCNA）和表皮生长因子（EGF）表达，以及通过DNA流式细胞术分析的倍体状态被用作增殖相关标志物。有丝分裂的存在、高PCNA评分和DNA非整倍体与组织学亚型、患者年龄、性别或肿瘤范围无关。只有EGF表达与组织学亚型显著相关。这一发现表明，EGF表达可能是预测甲状腺乳头状癌预后的最可靠标志物。
