Gormley E A, Griffiths D J, McCracken P N, Harrison G M
Department of Applied Sciences in Medicine, University of Alberta, Edmonton, Canada.
Br J Urol. 1993 Mar;71(3):265-9. doi: 10.1111/j.1464-410x.1993.tb15940.x.
The relationship between medication and incontinence was studied retrospectively in 128 elderly patients enrolled in an incontinence study. Patients were taking up to 18 non-topical medications but most of these were unlikely to have a significant urological effect. Nevertheless, 62% of patients were receiving, for other medical problems, up to 4 drugs which could potentially affect the lower urinary tract. These were classified by their mode of action. The most common types of urologically active medication, apart from diuretics, were calcium channel blockers, used by 21% of patients, and tricyclic antidepressants, used by 12%. The urodynamic findings in patients on different types of medication were compared. Patients with urodynamically proven urge incontinence who were on calcium channel blockers had significantly less urine loss than those not on the drug. Tricyclic antidepressants have been used in the treatment of urge incontinence; in this study urine loss was less severe among those receiving tricyclics, although the differences were not significant. A few patients on beta-blockers apparently had more severe urge incontinence. Drugs prescribed to the elderly for non-urological medical problems can affect the lower urinary tract and may have some effect, either beneficial or adverse, on incontinence.
对128名参与尿失禁研究的老年患者进行了回顾性研究，以探讨药物与尿失禁之间的关系。患者服用多达18种非局部用药，但其中大多数药物不太可能产生显著的泌尿系统影响。尽管如此，62%的患者因其他医疗问题正在服用多达4种可能影响下尿路的药物。这些药物按其作用方式分类。除利尿剂外，最常见的具有泌尿学活性的药物类型是钙通道阻滞剂（21%的患者使用）和三环类抗抑郁药（12%的患者使用）。对服用不同类型药物的患者的尿动力学检查结果进行了比较。经尿动力学证实为急迫性尿失禁且正在服用钙通道阻滞剂的患者，其尿量损失明显少于未服用该药物的患者。三环类抗抑郁药已用于治疗急迫性尿失禁；在本研究中，服用三环类药物的患者尿量损失较轻，尽管差异不显著。少数服用β受体阻滞剂的患者明显有更严重的急迫性尿失禁。为老年患者非泌尿系统疾病开的药会影响下尿路，可能对尿失禁产生有益或有害的影响。
