天花粉蛋白作为一种终止小鼠早期妊娠的堕胎药。
Trichosanthin as an abortifacient for terminating early pregnancy in mice.
作者信息
Chan W Y, Ng T B, Yeung H W
机构信息
Department of Anatomy, Faculty of Medicine, Chinese University of Hong Kong.
出版信息
Int J Fertil. 1993 Mar-Apr;38(2):99-107.
OBJECTIVE
To test trichosanthin--a basic protein from Trichosanthes kirilowii--as abortifacient, and effect on subsequent pregnancy.
METHODS
Female mice, on day 1, 2, or 3 of pregnancy, given 0.10, 0.15, 0.20, or 0.25 mg/25 g body wt., intraperitoneally. Animals killed on day 11 for assessment of abortion, or day 4 for examination of embryos. Subsequent pregnancy was tested after 20 days in mice that had aborted completely.
RESULTS
With 0.20-0.25 mg/25 g, 64-80% aborted. At day 4, pre-implantation development was disturbed, many still being morulae (in the oviduct). Subsequent pregnancies and offspring were entirely normal.
CONCLUSIONS
Trichosanthin, long used to effect abortion in humans in China, has congruent effects on ICR laboratory mice.
目的
测试天花粉蛋白——一种来自栝楼的碱性蛋白质——作为堕胎药的效果，以及对后续妊娠的影响。
方法
怀孕第1、2或3天的雌性小鼠，腹腔注射0.10、0.15、0.20或0.25毫克/25克体重的药物。在第11天处死动物以评估堕胎情况，或在第4天处死以检查胚胎。在完全流产的小鼠中，20天后测试后续妊娠情况。
结果
给予0.20 - 0.25毫克/25克体重时，64 - 80%的小鼠流产。在第4天，植入前发育受到干扰，许多胚胎仍为桑椹胚（在输卵管中）。后续妊娠和后代完全正常。
结论
在中国长期用于人类堕胎的天花粉蛋白，对ICR实验小鼠有相同的作用。
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