McKeon T W, Zigmond R E
Department of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, OH 44106-4975.
Brain Res. 1993 Apr 2;607(1-2):345-8. doi: 10.1016/0006-8993(93)91529-2.
Electrical stimulation of the preganglionic fibers innervating the rat superior cervical ganglion (SCG) produces both short-term and long-term increases in tyrosine hydroxylase (TH) activity that are not completely blocked by nicotinic antagonists. Vasoactive intestinal peptide (VIP) and secretin, two neuropeptides known to produce short-term increases in TH activity, were examined for their ability to produce long-term increases in this enzyme activity. Culturing the SCG in the presence of either peptide produced a 30-50% increase in TH activity measured 2 days later. The results raise the possibility that one of these peptides or a related molecule participates in the transsynaptic induction of ganglionic TH.
对支配大鼠颈上神经节（SCG）的节前纤维进行电刺激，可使酪氨酸羟化酶（TH）活性产生短期和长期增加，而烟碱拮抗剂并不能完全阻断这种增加。血管活性肠肽（VIP）和促胰液素是已知能使TH活性产生短期增加的两种神经肽，研究了它们使该酶活性产生长期增加的能力。在两种肽存在的情况下培养SCG，2天后测得TH活性增加了30%-50%。这些结果增加了一种可能性，即这些肽中的一种或相关分子参与了神经节TH的跨突触诱导。
