Jha P K, Beral V, Peto J, Hack S, Hermon C, Deacon J, Mant D, Chilvers C, Vessey M P, Pike M C
Cancer Epidemiology Unit, Imperial Cancer Research Fund, Oxford, UK.
Lancet. 1993 May 1;341(8853):1116-8. doi: 10.1016/0140-6736(93)93128-n.
Human papillomaviruses (HPVs) play an important part in the development of cervical cancer, but the role of other infectious agents, such as herpes simplex virus (HSV), is not clear. We assayed serum samples collected from 219 women with cervical cancer and from 387 controls for antibody to infectious agents. HPV 16-E7 and/or HPV 18-E7 antibodies were significantly related to cervical cancer risk (RR 1.9, 95% CI 1.2-3.2). Antibodies to HSV types 1 and 2, Chlamydia trachomatis, and to multiple infectious agents were associated with cervical cancer when seroprevalence rates in all cases and controls were compared, but when HPV-seropositive cases and controls were compared these associations were weaker and non-significant. This finding suggests that past infections with sexually transmitted infections other than HPV may be surrogate markers of exposure to HPV, and of no separate aetiological significance.
人乳头瘤病毒（HPV）在宫颈癌的发生发展中起着重要作用，但其他感染因子，如单纯疱疹病毒（HSV）的作用尚不清楚。我们检测了从219名宫颈癌女性和387名对照者中采集的血清样本，以检测其针对感染因子的抗体。HPV 16-E7和/或HPV 18-E7抗体与宫颈癌风险显著相关（相对风险1.9，95%置信区间1.2 - 3.2）。当比较所有病例和对照者的血清阳性率时，1型和2型HSV、沙眼衣原体以及多种感染因子的抗体与宫颈癌相关，但当比较HPV血清阳性的病例和对照者时，这些关联较弱且无统计学意义。这一发现表明，除HPV外的既往性传播感染可能是接触HPV的替代标志物，并无独立的病因学意义。
